The mast cell

Abstract

Mast cells are immune cells that are arguably the most closely associated cell type with allergic reactions. They were originally discovered by Frederick von Recklinghausen in 1863 and named by Paul Ehrlich in 1877 [1]. They originate in the bone marrow, but unlike other types of cells such as basophils they mature while circulating in the body, usually when reaching a specific tissue site. Mast cells are a common “participate” not only in allergic reactions but also in wound healing, immune tolerance and importantly in defense against pathogens [2]. As mentioned, they are similar to the basophil in terms of function and appearance. Both cells express CD34. Mast cells are present in most tissues are very prevalent near the skin surface and mucosa and conjunctiva. Allergic reactions of the eye may be the most reported types of allergic reaction, simply because they are the most “visible” to both the victim and to others and may in rare cases lead to blindness.