Toll-Like Receptors-Autophagy Immuno-Inflammatory “Molecular Cross-talks” in Hypoxic Tumor Microenvironment in Complex Neurological Diseases Primarily Glioblastoma: Translational Research Impact in Genetically Susceptible Population-Pools in Covid-19/ Omicron Pandemic Era

Abstract

Deciphering the underlying cellular/molecular and genetic basis of inflammatory tumor microenvironment in complex neurological diseases especially glioblastoma warrants dynamic collaborations in clinical research worldwide. The overwhelming disproportionate share of morbidity and mortality amongst genetically and ethnically heterogeneous population-pools symptomatic of early vs advanced stage/grade brain tumors is certainly intriguing; adequate public health-oriented endeavors for meaningful patient-centric evidence-based pragmatic outcomes for successful design and development of clinically validated biomarkers for glioblastoma management would prove to be a “neurophysiological genetic roadmap” for patient-friendly immunotherapeutically safe precision medicine-oriented treatment. In my expert opinion, enthusiastic clinical researchers worldwide should dynamically collaborate and actively investigate the complex neuro-immune