VALUES OF HEART RATE VARIABILITY IN THE LONG-TERM PERIOD IN PATIENTS WITH ATRIAL FIBRILLATION TREATED WITH ALLAPININ

Stolyarov V.V., Rybakova T.A., Bataev Kh.M.
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Abstract

Abstract. The study shows the values of heart rate variability in patients with paroxysmal atrial fibrillation treated with allapinin monotherapy and a combination of allapinin with metoprolol, allapinin with sotahexal and allapinin with diltiazem with preventive antiarrhythmic therapy. Analysis of heart rate variability allows you to determine the state of the autonomic nervous system. A high probability of an unfavorable outcome of diseases of the cardiovascular system is observed with the predominance of the tone of the sympathetic nervous system and a decrease in the tone of the parasympathetic nervous system. A decrease in heart rate variability and a predominance of sympathetic nervous system tone are predictors of the occurrence of another paroxysm in patients with paroxysmal atrial fibrillation. Indicators of heart rate variability are of great importance in the selection of antiarrhythmic therapy. The initial predominance of the tone of the parasympathetic nervous system in comparison with healthy ones and the absence of negative dynamics after 1 year was recorded in patients with paroxysmal atrial fibrillation with allapinin monotherapy. Patients treated with a combination of allapinin and metoprolol had a predominance of the tone of the parasympathetic nervous system initially compared with the healthy group and a transition to sympathicotonia after 1 year compared with healthy, control and their own baseline values. Patients receiving allapinin and sotahexal had no significant differences either at the beginning of the study or after 1 year. Predominance of sympathetic nervous system tone was registered in patients treated with allapinin and diltiazem by the end of 1 year of the study in comparison with a group of healthy.
allapinin治疗心房颤动患者长期心率变异性的价值
摘要该研究表明,在预防性抗心律失常治疗中,allapinin单药治疗、allapinin与美托洛尔、allapinin与索他己醛、allapinin与地尔硫卓联合治疗的阵发性心房颤动患者心率变异性的价值。对心率变异性的分析可以让你确定自主神经系统的状态。观察到心血管系统疾病的不利结果的高概率与交感神经系统张力的优势和副交感神经系统张力的降低有关。心率变异性的降低和交感神经系统张力的优势是发作性心房颤动患者发生另一次发作的预测因子。心率变异性指标对选择抗心律失常治疗具有重要意义。与健康人相比,阵发性心房颤动患者在接受allapinin单药治疗一年后,其副交感神经系统张力的初始优势和负动力的缺失被记录下来。与健康组相比,使用allapinin和美托洛尔联合治疗的患者最初副交感神经系统的张力占优势,与健康组、对照组和他们自己的基线值相比,1年后过渡到交感神经张力。接受allapinin和sotahexal治疗的患者在研究开始时或1年后均无显著差异。在1年的研究结束时,与一组健康患者相比,接受allapinin和diltiazem治疗的患者交感神经系统张力占优。
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