Clinically Important Meperidine Toxicities

Abstract

The pharmacokinetics, metabolism, alleged adverse effects and evidence on adverse effects of meperidine are compared to those of other commonly used opioids. Comparative effects of meperidine and other opioids on respiratory depression, spasmogenicity, newborns when the drugs are used in labor and delivery and neurological status are discussed. Anecdotal reports of fewer side effects of meperidine as compared to morphine and other opioids may be due to comparison of non-equivalent doses in some cases. Some evidence that indicates differences between meperidine and other opioids does not indicate clinically important differences. Alternative medications to meperidine are suggested for cases when such alternatives may be desired.