[Epilepsy and hypohaptoglobinemia].

Abstract

The serum haptoglobin (Hp) of 24 patients with familial epilepsy and 21 relatives of them, as well as 21 patients with secondary epilepsy was determined by the method of linear concentration gradient (4-22%) polyacrylamide gel electrophoresis. The mean value of their serum Hp was significantly reduced to 54.83% (P less than 0.001), 76.48% (P less than 0.01) and 74.91% (P less than 0.01) of that of the control (109.63 mgHb/dl, n = 201) respectively. The possible pathophysiological mechanism of the epileptic seizures and reduced serum Hp level was discussed briefly.