Synthesis, Characterization and Anticancer Studies of Fe(II)Cysteinedithiocarbamate Complex

Proceedings of the 1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia Pub Date : 1900-01-01 DOI:10.4108/eai.2-5-2019.2284628

R. Irfandi, P. Prihantono, I. Raya, D. Kartina, R. Riswandi

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引用次数: 2

Abstract

Fe(II)cysteindithiocarbamate complex has been synthesized by an in-situ method. Complex characterized using Ultra Violet Visible (UV-Vis), Infra Red (IR), melting point and molar conductivity. The presence of UV-Vis maximum spectrums of Fe(II)cysteindithiocarbamate at 245 nm and 354 nm indicated that electronic transition π→π* dan n→π* of CS2 and N=C=S. While the presence of IR spectra at the wavelength in the region of 393-540 cm indicated that has been coordination occurred between Fe(II) with Sulphur (S), Nitrogen (N) and Oxygen(O) atoms from cysteinedithiocarbamate ligands. Anticancer activity tests of Fe(II) complex and metals without ligands on the breast cancer cell line (MCF-7) were carried out in vitro. The results of the cytotoxicity test showed that Fe(II) complex had the potential as an anticancer for MCF-7 cancer cells compared to metals without ligands which showed a non-toxic effect on cancer cells.

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铁(II)半胱氨酸二硫代氨基甲酸酯配合物的合成、表征及抗癌研究

采用原位法合成了铁(II)半胱氨酸二硫代氨基甲酸酯配合物。用紫外可见(UV-Vis)、红外(IR)、熔点和摩尔电导率对配合物进行表征。Fe(II)半胱氨酸二硫代氨基甲酸酯在245 nm和354nm处的紫外可见最大光谱表明CS2的电子跃迁π→π*和n→π*， n =C=S。而393 ~ 540 cm波段的红外光谱表明，铁(II)与半胱氨酸二硫代氨基甲酸酯配体中的硫(S)、氮(N)和氧(O)原子发生了配位。研究了铁(II)配合物和不含配体的金属对乳腺癌细胞株(MCF-7)的体外抗癌活性。细胞毒性试验结果表明，与不含配体的金属相比，Fe(II)配合物对MCF-7癌细胞具有潜在的抗癌作用，对癌细胞无毒。

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Proceedings of the 1st International Conference on Science and Technology, ICOST 2019, 2-3 May, Makassar, Indonesia

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