Effects of myocardial electrotonic interaction on the sequence of excitation and repolarisation and on T wave polarity. Computer modelling experiments.

M Malik, A J Camm
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Abstract

A computer model of a 3-dimensional rectangular block of myocardial tissue (3969 cells) has been used to investigate the influence on excitation and repolarisation sequences and on the modelled electrocardiographic T wave of (a) electrotonic interaction, (b) intrinsic distribution of refractoriness, and (c) the speed of repolarisation of action potentials. The model allowed electrotonic interactions to be investigated separately during the depolarisation and repolarisation phases. Scales of 14 values of the strength of electrotonic interaction during the depolarisation phase, 14 values of the strength of electrotonic interaction during the repolarisation phase, 3 shapes of action potential, and 5 distributions of tissue refractoriness were selected and all 2940 combinations were examined. In each experiment, the tissue model was artificially excited and the resulting excitation and repolarisation sequences were simulated. The results of the study suggested that electrotonic interactions between excited cells can cause non-uniform speed of propagation which, by means of the phase shifts of action potentials, contributes to the inversion of the repolarisation sequence and to the physiologic orientation of T waves. Experiments with this model did not support the hypothesis that simple electrotonic smoothing of the differences in repolarisation phases due to the excitation phase shift of action potentials reverses the repolarisation sequence and explains T wave polarity.

心肌电紧张相互作用对兴奋和复极顺序及T波极性的影响。计算机模拟实验。
使用三维矩形心肌组织块(3969个细胞)的计算机模型来研究(A)电紧张相互作用,(b)耐火度固有分布,(c)动作电位复极速度对兴奋和复极序列以及模拟心电图T波的影响。该模型允许在去极化和复极化阶段分别研究电紧张相互作用。选取去极化期14个电紧张相互作用强度量表、复极化期14个电紧张相互作用强度量表、3种动作电位形状和5种组织耐火度分布量表,对2940种组合进行了检测。在每个实验中,组织模型都被人工激发,并模拟产生的激发和复极化序列。研究结果表明,兴奋细胞之间的电紧张相互作用可以引起传播速度的不均匀,通过动作电位的相移,有助于T波的复极化序列和生理取向的反转。该模型的实验不支持简单的电紧张平滑由于动作电位的激发相移引起的复极化相位差异,从而逆转复极化序列并解释T波极性的假设。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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