CHILDHOOD OBESITY AS A PREDICTOR OF TYPE 2 DIABETES MELLITUS IN ADULTS : A SYSTEMATIC REVIEW

Dea Nabila Ratu Alicia
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Abstract

The United States of America and other countries all over the world are not the only ones experiencing a growing epidemic of childhood obesity as a major threat to public health. This is a problem that affects countries in all parts of the world. At the moment, one child in the United States out of every three is either overweight or obese. This problem is especially prevalent among young people. Obesity treatments need to be community-based and environment-focused in order to put an end to the epidemic of obesity. As the prevalence of pediatric obesity continues to climb, comorbidities that were once regarded of as "adult" illnesses, such as type 2 diabetes mellitus, hypertension, nonalcoholic fatty liver disease, obstructive sleep apnea, and dyslipidemia, are becoming increasingly common in children. Even a slight gain in weight before puberty is associated with an increased risk of type 2 diabetes and cardiovascular disease later in life; hence, immediate action is required. The presence of insulin in the bloodstream despite a decreased tissue sensitivity to insulin is characteristic of type 2 diabetes. There is a strong correlation between being overweight or obese and developing type 2 diabetes. As a result, the hypothesis that overeating is the root cause of Type 2 Diabetes. Due to muscle and islet -cell insulin resistance, which promotes greater glucagon production, obesity raises the chance of developing type 2 diabetes mellitus in persons who are already genetically susceptible to developing the condition. On the other hand, obesity is not the primary risk factor for developing type 2 diabetes.
儿童期肥胖作为成人2型糖尿病的预测因子:一项系统综述
美国和世界各地的其他国家并不是唯一一个儿童肥胖日益流行的国家,这是对公众健康的主要威胁。这是一个影响世界各地国家的问题。目前,美国每三个孩子中就有一个超重或肥胖。这个问题在年轻人中尤为普遍。肥胖治疗需要以社区为基础,以环境为重点,以结束肥胖的流行。随着儿童肥胖的患病率持续攀升,曾经被视为“成人”疾病的合并症,如2型糖尿病、高血压、非酒精性脂肪性肝病、阻塞性睡眠呼吸暂停和血脂异常,在儿童中变得越来越普遍。即使在青春期前体重轻微增加,也会增加以后患2型糖尿病和心血管疾病的风险;因此,需要立即采取行动。血液中存在胰岛素,尽管组织对胰岛素的敏感性降低,这是2型糖尿病的特征。超重或肥胖与患2型糖尿病有很强的相关性。因此,暴饮暴食是2型糖尿病的根本原因的假设。由于肌肉和胰岛细胞的胰岛素抵抗,促进了胰高血糖素的产生,肥胖增加了遗传易感性的人患2型糖尿病的机会。另一方面,肥胖并不是患2型糖尿病的主要危险因素。
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