To study the effect of early zinc supplementation on growth of low birth weight infants- A randomised control trial

S. Gaikwad, J. Patel, Ashwini Kundalwal
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Abstract

The present study was carried out with aim to study the effect of early zinc supplementation on growth of low birth weight infants — A randomised control trial in the Department of Paediatrics at Government Medical College and Hospital, to study effect of zinc supplementation on LBW infants. The registered subjects were then randomized into Intervention (Group I, Case) and Non-Intervention (Group II, control) groups using computer generated random number technique. Cases (Group I) were given zinc supplements Syrup Zinc acetate (Syp. Zinconia 5ml=20mg) 2mg/kg single dose in morning at 8 a.m. daily and multivitamins drops 10 drops per day (Vit.A 375 µg, Vit.B1-B6, Vit.D 5µg) for duration of 6 weeks and Controls (Group II) were given multivitamins drops (Vit.A 375 µg, Vit.B1-B6, Vit.D 5µg) 10 drops per day for duration of 6 weeks.There was no significant difference in cases and controls in respect to males and females. No significant difference (p value >0.05) in pattern of intrauterine growth in cases and controls.Fifty percent of our study subjects in both group were of weight more than 1400 grams.Zinc had significant effect on weight gain of pre-terms (AGA and SGA) and term AGA only at the end of 6 weeks. There was only significant effect on length in mean difference at 6 weeks when compared to at 48 hours. There was highly significant difference in supplement group (cases) in weight/length at 6 weeks with minimal or insignificant effect on chest circumference and head circumference.
研究早期补锌对低出生体重儿生长发育的影响——一项随机对照试验
本研究的目的是研究早期补锌对低出生体重婴儿生长的影响——在政府医学院和医院儿科进行的一项随机对照试验,研究补锌对低出生体重婴儿的影响。然后使用计算机生成随机数技术将注册的受试者随机分为干预组(第一组,病例)和非干预组(第二组,对照组)。1组患者给予糖浆醋酸锌(Syp;锌5ml=20mg) 2mg/kg单剂,每天早上8点服用,复合维生素滴剂每天10滴(Vit)。A 375µg, Vit。B1-B6,维特。D 5µg),持续6周,对照组(II组)给予复合维生素滴剂(Vit)。A 375µg, Vit。B1-B6,维特。D 5µg),每天10滴,持续6周。在男性和女性的病例和对照中没有显著差异。病例组与对照组宫内生长模式差异无统计学意义(p值>0.05)。两组中都有50%的研究对象体重超过1400克。锌仅在6周结束时对早产儿(AGA和SGA)和中期AGA的体重增加有显著影响。与48小时相比,6周时的平均差异长度只有显著影响。在6周时,补充组(病例)的体重/长度差异极显著,而对胸围和头围的影响很小或不显著。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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