Oral Cobalamin Therapy for the Patient with Biermer’s Disease

Abstract

Biermer’s disease also called: Addison’s anemia or in old textbooks, pernicious anemia, is an autoimmune disease, caused by impaired absorption of cobalamin (vitamin B12) owing to the neutralization of intrinsic factor action in the setting of immune atrophic gastritis [1]. In adults and elderly patients, this form of megaloblastic anemia is one of the leading causes of cobalamin deficiency, with the recent described and recognized disorder called food-cobalamin malabsorption. Biermer’s disease, as several autoimmune disorders, has a genetic component.