Association between GSTM1, GSTT1, and GSTP1 polymorphisms and gastric cancer risk, and their interactions with environmental factors.

Zhe Chen, J. Xian, Liangping Luo
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引用次数: 21

Abstract

Glutathione S-transferase (GST) is an important member of phase II metabolic enzymes; GSTM1, GSTT1, and GSTP1 belong to three subfamilies of the GST enzyme. Polymorphisms in GSTM1, GSTT1, and GSTP1 could affect detoxification processes, and increase individuals' susceptibility to cancers. We aimed to investigate the association between GSTM1, GSTT1, and GSTP1 polymorphisms and the risk of gastric cancer in a Chinese population. In addition, we also examined the effect of gene-environmental interactions, and their effect on risk of this cancer. Between July 2013 and June 2015, we recruited 242 gastric cancer patients and 396 healthy controls for our study. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to characterize genetic polymorphisms in GSTM1, GSTT1, and GSTP1. We observed that the Val/Val genotype of GSTP1 was associated with increased risk of gastric cancer when compared with the Ile/Ile genotype (OR = 3.19, 95%CI = 1.84-5.56). Moreover, the Val allele of GSTP1 was associated with higher susceptibility to gastric cancer as compared with the Ile allele (OR = 1.52, 95%CI = 1.19-1.93). However, GSTM1 and GSTT1 polymorphisms did not affect the development of gastric cancer. In conclusion, our study indicated that GSTP1 Ile105Val, but not GSTM1 and GSTT1 polymorphisms, was associated with risk of gastric cancer.
GSTM1、GSTT1和GSTP1多态性与胃癌风险的关系及其与环境因素的相互作用
谷胱甘肽s -转移酶(GST)是II期代谢酶的重要成员;GSTM1、GSTT1和GSTP1属于GST酶的三个亚家族。GSTM1、GSTT1和GSTP1的多态性可能影响解毒过程,并增加个体对癌症的易感性。我们的目的是研究GSTM1、GSTT1和GSTP1多态性与中国人群胃癌风险之间的关系。此外,我们还研究了基因-环境相互作用的影响,以及它们对患这种癌症风险的影响。2013年7月至2015年6月,我们招募了242名胃癌患者和396名健康对照者进行研究。采用聚合酶链反应-限制性片段长度多态性分析对GSTM1、GSTT1和GSTP1的遗传多态性进行了表征。我们观察到,与Ile/Ile基因型相比,GSTP1的Val/Val基因型与胃癌风险增加相关(OR = 3.19, 95%CI = 1.84-5.56)。此外,GSTP1的Val等位基因与Ile等位基因相比,与更高的胃癌易感性相关(OR = 1.52, 95%CI = 1.19-1.93)。然而,GSTM1和GSTT1的多态性对胃癌的发展没有影响。总之,我们的研究表明GSTP1 Ile105Val多态性与胃癌风险相关,而不是GSTM1和GSTT1多态性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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