In-vivo characterization of a 0.8 – 3 µVRMS input-noise versatile CMOS pre-amplifier

Abstract

The following work presents a CMOS-integrated low-noise pre-amplifier (LNA) for bio-potential recordings, which is part of a multi-channel neural recording system. The versatile pre-amplifier channel features a tunable lower cut-off frequency from 0.2 Hz to 10 kHz, an upper cut-off frequency from 37.9 Hz to 11 kHz, and a middle-band gain from 41 to 45 dB. With its variable power consumption from 3.3 μW to 1 mW, the input-referred noise can be set from 2 down to 0.8 μVRMS. The pre-amplifier, fabricated in a 0.35 μm CMOS process, was successfully tested for ECG, EMG, and EEG applications.