To Evaluate the Efficacy and Safety of Autologous Platelet Rich Fibrin Matrix in the Treatment of Non-Healing Ulcer of Various Aetiology

Abstract

extraction [3] and transplant on the wound bed, epidermal grafting, etc. Recently, the focus has shifted on to growth factors which include therapies like recombinant growth factors and Platelet Rich Plasma (PRP). Platelet Rich Fibrin Matrix (PRFM), a next generation PRP is the latest addition which is based on the premise of slow and sustained release of growth factors [4] mimicking the natural wound healing process. The concentration of platelets is higher in PRP but a study showed that, when incorporated into fibrin, the mean concentration of growth factors in the platelet concentrates was three times or more than that observed with conventional platelet-rich plasma. The membrane can be easily placed on the ulcer with minimal chances of displacement. Thus giving PRFM an edge over PRP in wound healing. Autologous PRFM is prepared from patients own blood thus being free from risk of communicable pathogens, is easy to prepare with long lasting as well as good clinical results. the Efficacy and Safety of Autologous Platelet Rich Fibrin Matrix in the Treatment of Non-Healing Ulcer of Various Abstract Rationale: Chronic Non-Healing Ulcers (NHU) is those which persists for more than 6 weeks and may be due to underlying factors like venous stasis, peripheral neuropathy, immobility, etc. Chronic ulcers are associated with decreased quality of life and also pose a financial burden on the patient as well as society. The failure of NHU to respond to the various modalities available lead to the search for growth factors requisite for wound healing resulting in the development of Platelet Rich Plasma (PRP). Platelet Rich Fibrin Matrix (PRFM) is a next generation of PRP that has shown promising result in our study. Objectives: This study was done to evaluate the efficacy and safety of autologous platelet rich fibrin matrix in the treatment of non-healing ulcer of various aetiology. Results: All the ulcers responded to the treatment with decrease in pain and discharge beginning from first sitting. The mean time to ulcer healing was 6.43+2.33 weeks. There was 100% improvement in volume at the end of 8 weeks and 96% improvement in area at the end of 12 weeks. Conclusion: This study demonstrates that Autologous PRFM is a safe and efficacious method for the treatment of non-healing ulcer and at the same time simple and highly cost effective method.