[The effect of therapy with cytostatics and immunomodulators on mitotic pathology in Lewis tumor cells in mice].

Iu N Potapov, T V Krutova, V S Pashkova, D V Khaleev
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Abstract

The effect of cytostatics (methylnitrosourea and methotrexate), immunomodulators (thymalin and reaferon) and their combinations on the mitotic pathology of mice Lewis tumour cells was studied. It was revealed that chemotherapy with these agents changed the interrelation between mitotic phases and somewhat enhanced the incidence of pathologic mitoses mainly connected with the damage of mitotic apparatus. Immunomodulators differently affected the cytostatic activity of antitumour agents that may be associated with their mechanisms of action.

[细胞抑制剂和免疫调节剂对小鼠Lewis肿瘤细胞有丝分裂病理的影响]。
研究了细胞抑制剂(甲基亚硝基脲和甲氨蝶呤)、免疫调节剂(胸腺素和干扰素)及其联合用药对小鼠Lewis肿瘤细胞有丝分裂病理的影响。结果表明,这些药物的化疗改变了有丝分裂期的相互关系,并在一定程度上增加了主要与有丝分裂器损伤有关的病理性有丝分裂的发生率。免疫调节剂不同程度地影响抗肿瘤药物的细胞抑制活性,这可能与其作用机制有关。
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