Dielectrophoresis: Characterization of Triple-Negative Breast Cancer using Clausius-Mossotti Factor

2018 IEEE International Conference on Semiconductor Electronics (ICSE) Pub Date : 2018-08-01 DOI:10.1109/SMELEC.2018.8481322

Nur Mas Ayu Jamaludin, M. R. Buyong, Muhammad Khairulanwar Abdul Rahim, A. A. Hamzah, Burhanuddin Yeon Mailis, B. Bais

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引用次数: 3

Abstract

This paper describes a new possible application of dielectrophoresis (DEP) in breast cancer detection. Breast cancer is one of the most common cancer diseases in Malaysia which makes 17.7% of all cases reported between 2007 and 2011. This research aims to determine the dielectric properties of biophysical and biochemical of triple-negative breast cancer (TNBC). The manipulation of TNBC will be on the detection and enumeration based on polarization factor between permittivity and conductivity of TNBC and suspended medium. The results of analytical modelling prove that there are dynamic changes in the dielectric values, which are the permittivity and conductivity values between TNBC cell and medium when the frequency input value is changed. The findings offer a framework for anticipating TNBC dielectric detection response on the basis of structure-function relationship and suggest that dielectrophoresis lab-on-chip (DLOC) application for TNBC detection and enumeration should be widely used as a surface marker-independent method and provide high precision analysis in cancer progression and treatment effectiveness.

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双电泳:用克劳修斯-莫索蒂因子表征三阴性乳腺癌

本文介绍了dielectrophoresis (DEP)在乳腺癌检测中的一种新的应用前景。乳腺癌是马来西亚最常见的癌症疾病之一，在2007年至2011年期间报告的所有病例中占17.7%。本研究旨在确定三阴性乳腺癌(TNBC)的生物物理生化介电特性。TNBC的操作将是基于TNBC与悬浮介质介电常数和电导率之间的极化因子来检测和计数。解析建模的结果证明，当频率输入值改变时，TNBC电池与介质之间的介电常数和电导率值会发生动态变化。该研究结果为基于结构-功能关系预测TNBC介电检测响应提供了一个框架，并提示dielectrophoresis lab-on-chip (DLOC)应用于TNBC检测和计数应作为一种不依赖于表面标记物的方法得到广泛应用，并在癌症进展和治疗效果方面提供高精度分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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2018 IEEE International Conference on Semiconductor Electronics (ICSE)

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