Pengaruh Pemberian Alpha Lipoic Acid Terhadap Perubahan Histopatologi Tikus Putih Yang Diinduksi Diet Tinggi Lemak

Abstract

Liver is one of the most vital organs that functions as a center for metabolism. One of the diseases that disrupt liver function with a high prevalence is NAFLD (Non Alcoholic Fatty Liver Disease). NAFLD is characterized by increased intracellular triglyceride accumulation. Increased lipid peroxidation can lead to Non Alcoholic Steato Hepatitis (NASH) and cirrhosis which induces proinflammatory cytokines. Alpha lipoic acid (ALA) is an antioxidant that has been widely used in treating metabolic syndrome. Based on several previous studies. ALA may be useful for the treatment of NAFLD by targeting various pathways in the development of NAFLD. The study divided animals into five groups as standard feed; high fat diet (HFD); HFD and ALA 100 mg/kg BW i.p .; HFD and ALA 100 mg/kg BW i.p also repaired fed; HFD and repaired – fed. Based on the results of the study, it can be concluded that ALA as an antioxidant can improve liver cell histopathology in NAFLD rat induced high fat diet.