Minimizing the risk of adverse events with injectable poly-L-lactic acid

Abstract

Injectable poly-L-lactic acid (SculptraAE) is an effective and durable treatment for volume correction/restoration (in people with human immunodeficiency virus treatment-related facial fat loss [lipoatrophy]) and is well tolerated when administered correctly. Incorrect administration technique and suboptimal preparation of poly-L-lactic acid can lead to the formation of papules and nodules. In order to minimize the risk of development of these lesions, poly-L-lactic acid should be reconstituted correctly and injected subcutaneously at the junction of the dermis and subcutaneous fat using the appropriate technique tailored to both the patient and area of correction. Here we overview the best administration techniques for poly-L-lactic acid in order to minimize the potential for adverse effects and optimize treatment outcomes. Used correctly, poly-L-lactic acid is associated with a