A Meta-analysis of efficacy and safety of Banxia Xiexin decoction on ulcerative colitis

Abstract

: Objective: To evaluate the clinical efficacy and safety of Banxia Xiexin Decoction in the treatment of ulcerative colitis(UC). Methods: The Cochrane Library, PubMed, Embase, CBM, CNKI, VIP and Wanfang databases were searched by computer, and the clinical randomized controlled trials(RCTs) of Banxia Xiexin Decoction in the treatment of UC were included with the method of manual retrieval. The retrieval time was from the establishment of each database to March 16,2021. Meta-analysis was completed Rev Man 5.3. Results: This study included 16 articles,1332 patients. Meta-analysis showed that the total effective rate was [RR = 1.29, 95%CI:1.23~1.36,Z=9.82(P ＜ 0.01)];The cure rate [RR=1.72,95%CI:1.43~2.06,Z=5.79(P ＜ 0.01)];The incidence of adverse reactions was [RR=1.2 9,95%CI:0.27~0.65,Z=3.88(P=0.0001)];Symptom disappearance time ① Abdominal pain disappearance time: [MD =-4.45, 95%CI:-5.03~-3.86,Z=14.99(P ＜ 0.01)], ② Diarrhea disappearance time: [MD=- 2.7 0,95%CI:-3.27~-2.13, Z=9.28(P ＜ 0.01)], ③ Skeptics tool disappearance time: [MD=-2.55, 9 5%CI:-3.09~-2.02,Z=9.32(P ＜ 0.01)];The levels of inflammatory factors TNF -α and IL- 1 ① TNF -α: [MD=-5.3 6,95%CI:-7.70~-3.02,Z=4.49(P ＜ 0.01)], ② IL-1 :[MD =-0.41, 9 5%CI:-0.77~-0.06,Z=6.50(P =0.02)]; Conclusions: Curative Effect and Safety of Modified Banxia Xiexin Decoction on UC. symptoms of diarrhea, abdominal pain, fullness of stuffiness, internal urgency and weight loss. Experiments and clinical show that Banxia Xiexin Decoction has advantages in the treatment of UC. In order to clarify the efficacy and safety of Banxia Xiexin Decoction in the treatment of UC, based on the idea of evidence-based medicine, Meta analysis method is used to systematically evaluate its safety, so as to provide more reliable evidence for clinical treatment.