The effect of intravenous administration of propofol, thiopental, or propofol plus thiopental mixture in dogs undergoing experimentally liver insufficiency

Abstract

The present study was aimed to evaluate anesthetic properties, clinicphysiological and hemato-biochemical effects of propofol alone, thiopental alone or propofol/thiopental mixture in dogs with experimental liver insufficiency. For this purpose, 9 apparently healthy male dogs exposure to electrocauterization to induce liver insufficiency model. The dogs were randomly divided into three groups; each group consists of three dogs. All dogs were premedicated with Xylazine Hcl (1mg/kg bwt/i.m). The induction of general anesthesia was done via i/v injection of 6 mg/kg bwt Propofol (group A); 5mg/kg bwt Thiopental (group B) and 3 mg/kg Propofol + 2.5 mg/kg Thiopental mixture (group C). Blood samples were collected from the three groups at15mins before anesthesia induction then at 15, 30 and 45 minutes after treatments for both clinico-physiological and hemato-biochemical evaluations. A mild alteration in some physiological parameters and hemato-biochemical values was observed after anesthesia induction in all groups, but it still safe induce general anesthesia in dogs affected with liver insufficiency. However, Propofol /Thiopental mixture was induced a rapid, smooth induction and a longer duration of anesthesia with complete muscle relaxation which is suitable for all most surgical operations.