The Effect of Bajakah (Spatholobus Littoralis Hassk) Stem Extract on Calculation of Leukocyte in Mice (Mus Musculus)

Abstract

Background: Oxidative stress plays a role in the obesity mechanism, thus leads to premature aging. Bajakah tampala is a plant that has a great potential to be developed as a medicinal, flavonoids, and tannins. High antioxidant capacity in Bajakah stem may effectively lessen oxidative stress and reduce fat mass and body weight accordinfly. This study aimed to examine the effect of bajakah stem extract ( Spatholobus littoralis hassk ) on leukocyte level in mice ( Mus musculus ) Subjects and Methods : This was a randomized controlled trial was conducted at YATSI school of health sciences laboratorium, from June to August 2021. A sample of 30 mice aged 8-12 weeks, weighted 20-30 grams, and exposed to Salmonella typhimurium was selected for this study randomly. Sampele was divided into 5 groups and received: (1) aquadest (control). (2) bajakah stem extract dose 25 mb/kgBW, (3) bajakah stem extract dose 50 mg/kgBW, (4) bajakah stem extract dose 100 mg/kgBW. And (5) 30 mg/kgBW modulator drugs. The dependent variable was Bajakah stem extract. The independent variable was leukocytes. The data were analyzed by ANOVA test. Results: Bajakah stem extract dose 100 mg/kgBW reduced leukocytes in mice exposed to Salmonella typhimurium (p<0.001). Conclusion: Bajakah stem extract dose 100 mg/kgBW reduced leukocytes in mice exposed to Salmonella tyhimurium.