Salivary Analysis Of Iron In Oral Submucous Fibrosis: A Hospital Based Study

Suwarna M. Bhalerao
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Abstract

Background: Oral sub mucous fibrosis is one of the potentially malignant conditions of the oral cavity. Iron is meticulously studied in recent years to judge whether they have any modifying effects in the etiology of precancer and cancer. Aim of study was to evaluate levels of iron in the saliva in patients with OSMF. Methods: Study group comprised of 66 patients, out of which 22 cases of clinically diagnosed OSMF patients and 22 cases of betel nut habitual without OSMF and 22 cases of age and sex matched control healthy patients were recruited. Estimation of Iron by Ferrozine method in Saliva was carried out by using Spectrophotometer. The statistical analysis was carried out. Results: Level of iron in saliva was significantly decreased in OSMF patients when compared to betel nut habitual and control group which were statistically significant. Conclusion: The present study, all the cases of OSMF revealed reduction in iron levels which suggests that iron plays an important role in the pathogenesis and progression of OSM. In group II (Betel nut habituals without OSMF) patients showed decrease in iron levels which suggest that, betel nut quid with or without tobacco consumption may alter the serum and salivary levels of iron and plays an important role in the advancement of OSMF. Therefore regular monitoring of betel nut habituals should also be carried out because they are at higher risk of developing OSMF. The present study indicates that saliva also may be used as a potential non-invasive diagnostic tool to evaluate the iron In OSMF patients. Keywords: PMDs , OSMF, Salivary biomarkers, Iron and Saliva.
口腔黏膜下纤维化患者唾液铁含量分析:基于医院的研究
背景:口腔黏膜下纤维化是口腔潜在的恶性疾病之一。近年来,人们对铁进行了细致的研究,以判断它们是否对癌前病变和癌症的病因有任何改变作用。本研究的目的是评估OSMF患者唾液中的铁含量。方法:研究组共66例患者,其中临床诊断为OSMF的患者22例,无OSMF的槟榔习惯患者22例,年龄、性别匹配的健康对照患者22例。采用分光光度法测定唾液中铁的含量。进行统计分析。结果:OSMF患者唾液中铁含量较习惯性食用槟榔组和对照组明显降低,差异有统计学意义。结论:本研究所有OSMF病例均显示铁水平降低,提示铁在OSMF的发病和进展中起重要作用。在II组(无OSMF的习惯性槟榔)患者中,铁水平下降,提示有或没有吸烟的槟榔液可能改变血清和唾液中的铁水平,并在OSMF的进展中起重要作用。因此,也应该对吃槟榔的人进行定期监测,因为他们患OSMF的风险更高。本研究表明,唾液也可以作为一种潜在的非侵入性诊断工具来评估OSMF患者的铁含量。关键词:PMDs, OSMF,唾液生物标志物,铁和唾液。
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