The impact of IgG and IgM levels on clinical symptoms of people who have recovered from SARS-Cov-2

Abstract

The factors that influence SARS-CoV-2 antibody development are currently unknown. This study aims to detect these factors in COVID-19 patients who have recovered. ELISA was used to measure IgG and IgM levels in 188 serum samples. The results showed that 94.03% of patients had IgG and 5.22% had IgM. IgG concentrations peaked at 6 months after infection, while IgM concentrations peaked at 8 months after infection. This study revealed that the fever, joint, and muscle discomfort had the greatest percentages of 75% and 27.9%, respectively, with a significant association with IgG. There is a correlation between IgM and conjunctivitis at P <0.01. IgG and IgM levels correlate with age (15-35years). The varied levels of IgG and IgM have a distinct and visible effect on the overall clinical symptoms, with or without a correlation. The understanding of several biological and serological factors in patients who have recovered may be useful in this effort.