Total Oxyradical Scavenging Capacity as an Index of Susceptibility to Oxidative Stress in Marine Organisms

S. Gorbi, F. Regoli
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引用次数: 45

Abstract

Formation of reactive oxygen species (ROS) is a natural event for aerobic organisms, but it can be exacerbated by both biological and environmental factors. Cellular oxidative damage is well documented in aquatic organisms, and variations of antioxidants can be sensitive in revealing a pro-oxidant condition. Nonetheless, such effects are difficult to predict according to chemicals, kind of exposure, and species sensitivity. Measuring the overall efficiency of cellular antioxidants toward oxyradicals provides a more integrated assessment of susceptibility of a tissue to oxidative stress. Among the methods for analyzing total antioxidant capacity, the total oxyradical scavenging capacity (TOSC) assay offers the possibility to discriminate different oxyradicals, indicating the roles of these species or their metabolic pathways of formation, in the onset of oxidative disease. The TOSC assay has been widely used on marine organisms under natural and disturbed condition suggesting temporal and causal relationships among increased ROS formation, onset of antioxidant responses, and potential occurrence of oxidative damages and toxicity to cellular targets.
海洋生物氧化应激易感性指标的总自由基清除能力研究
活性氧(ROS)的形成是好氧生物的自然事件,但它可能受到生物和环境因素的加剧。细胞氧化损伤在水生生物中有很好的记录,抗氧化剂的变化可以敏感地揭示促氧化条件。然而,根据化学物质、暴露种类和物种敏感性,这种影响很难预测。测量细胞抗氧化剂对氧自由基的总体效率,可以更全面地评估组织对氧化应激的敏感性。在分析总抗氧化能力的方法中,总氧自由基清除能力(TOSC)测定提供了区分不同氧自由基的可能性,表明这些物种或其代谢形成途径在氧化性疾病发病中的作用。TOSC测定已广泛应用于自然和扰动条件下的海洋生物,表明ROS形成增加、抗氧化反应的发生、潜在的氧化损伤和对细胞目标的毒性之间存在时间和因果关系。
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