Symptoms in the Long Period after the Coronavirus Infection: Results of Long-Term Follow-Up

A. V. Melekhov, A. Agaeva, I. Nikitin
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Abstract

Background: assessment of type, prevalence and duration of residual symptoms after COVID-19 in recent studies is controversial because of differences in design. Aim: to assess the prevalence and severity of symptoms in the long-term period after COVID-19. Materials and methods: patients hospitalized with COVID-19 in the period 13.04.2020-10.06.2020 were interviewed by phone: 195 (58,2 %) convalescents at 143 (131-154) days after disease onset and 183 (54,6 % ) of them at 340 (325-351) days. Results: The subjective assessment of health status with 100-point scale before and after the COVID-19 was 95 (80-100) and 80 (70-96) points, p< 0,001, at first interview; 90 (80-100) and 80 (60-90) points, p< 0,001, at second one. Various complaints were detected in 63 % of respondents at the first interview and in 75 % at the second, the number of identified symptoms was 2 (0-6) and 4 (1-8) respectively. The most frequent complaints were weakness/fatigue (31.3 and 47.5 % of respondents), joint pain (31.3 and 47.5 %) and dyspnoe/shortness of breath (31.3 and 43.2 %). The growth of these indicators can be associated with a change in the interview methodology. The severity of the symptoms at second interview was low: fatigue — 3 (0-6) points, shortness of breath — 0 (0-3) points; joint pain, weakness and dyspnoe — 0 (0-5) points each. Conclusion: a decrease of health status can sustain for a long time after COVID-19. Symptoms persist in a significant proportion of convalescents, but their severity in the end of follow-up is quite low.
冠状病毒感染后长期症状:长期随访结果
背景:近期研究中对COVID-19后残留症状的类型、患病率和持续时间的评估存在争议,原因在于设计上的差异。目的:了解新型冠状病毒感染后的长期患病率和症状严重程度。材料与方法:对2020年4月13日~ 2020年6月10日住院的COVID-19患者进行电话访谈,其中发病后143 (131 ~ 154)d康复195例(58.2%),340 (325 ~ 351)d康复183例(54.6%)。结果:首次访谈时,患者主观健康状况100分制评分分别为95分(80 ~ 100分)和80分(70 ~ 96分),p< 0.001;90点(80-100)和80点(60-90),p< 0.001。63%的受访者在第一次访谈中发现了各种抱怨,75%的受访者在第二次访谈中发现了各种抱怨,确定的症状数量分别为2(0-6)和4(1-8)。最常见的抱怨是虚弱/疲劳(31.3%和47.5%的受访者),关节疼痛(31.3%和47.5%)和呼吸困难/呼吸短促(31.3%和43.2%)。这些指标的增长可能与访谈方法的变化有关。第二次面谈时症状的严重程度较低:疲劳-3(0-6)分,呼吸短促- 0(0-3)分;关节疼痛、无力、呼吸困难各0(0-5)分。结论:新型冠状病毒感染后健康状况的下降可持续较长时间。相当比例的恢复期患者症状持续存在,但随访结束时其严重程度很低。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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