Extracellular Vesicles and Their Role in Staphylococcus aureus Resistance and Virulence

B. Luz, V. Azevedo, Y. Le-loir, É. Guédon
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引用次数: 2

Abstract

Staphylococcus aureus is a pathogen of great importance to clinical and veterinary medicine. Recently, there has been a growing interest in S. aureus extracellular vesicles (EVs) in the pathogenesis of this bacterium. Released by living cells into the extracellular milieu, EVs are membranous structures carrying macromolecules such as proteins, nucleic acids, and metabolites. These structures play several physiological roles and are, among others, considered a mechanism of intercellular communication within S. aureus populations but also in trans kingdom interactions. S. aureus EVs were shown to transport important bacterial survival and virulence factors, such as β-lactamases, toxins, and proteins associated with bacterial adherence to host cells, and to trigger the production of cytokines and promote tissue inflammation. In this chapter, we will review the main studies regarding S. aureus EVs, including their composition and roles in host-pathogen interactions, and the possible applications of EVs for vaccines and therapy development against staphylococcal infections.
细胞外囊泡及其在金黄色葡萄球菌耐药性和毒力中的作用
金黄色葡萄球菌是一种对临床和兽医学具有重要意义的病原菌。最近,人们对金黄色葡萄球菌细胞外囊泡(EVs)的发病机制越来越感兴趣。电动汽车由活细胞释放到细胞外环境,是一种膜状结构,携带大分子,如蛋白质、核酸和代谢物。这些结构起着多种生理作用,除其他外,被认为是金黄色葡萄球菌群体内细胞间通信的机制,也被认为是跨界相互作用的机制。研究表明,金黄色葡萄球菌ev可运输重要的细菌存活和毒力因子,如β-内酰胺酶、毒素和与细菌粘附宿主细胞相关的蛋白质,并可触发细胞因子的产生并促进组织炎症。在这一章中,我们将回顾关于金黄色葡萄球菌的主要研究,包括它们的组成和在宿主-病原体相互作用中的作用,以及它们在葡萄球菌感染疫苗和治疗开发中的可能应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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