Abnormal Electrocardiographic Effects of Tricyclic Antidepressants

Scientific Inquiry and Review Pub Date : 1900-01-01 DOI:10.32350/sir.31.01

Huraira Hanif, Razia Iqbal, Sadia Sidra Aziz, Syeda Iman Fatima, Izzah Butt

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Abstract

The paper aims to review ECG and effects of Tricyclic Antidepressants (TCA) on ECG. ECG is the recording of the electrical conductivity of heart made by placing electrodes on the body. Antidepressants have lethal neurological and cardiovascular effects in depressive persons. TCA can cause abnormalities in the ECG pattern. It affects the conduction rate and slows the heart beat by blocking sodium channels that cause the elongation of QST complex which leads to abnormalities. QT is prolonged if > 440ms in men and > 460ms in women. Due to TCA, QT > 500ms that causes abnormalities. Brugada syndrome is also obtained by exposure to TCA. Doxepin slows down the conduction rate in patients with major depressive disorders. TCA causes symptomatic A-V blockage in patients with preexisting cardiovascular diseases. Desipramine and Immipramine cause sudden death in 6-9 years old children due to an overdose of these drugs. Antidepressants such as Agomelatine, Paroxetine, Serotonin Reuptake Inhibitors cause cardiac deformities in patients as well as pregnant women. Abnormality in ECG tells us about problems in the rhythmicity of heart. ECG can be used for the assessment of drugs that have electrophysiological effects.

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三环类抗抑郁药对心电图异常的影响

本文旨在综述三环类抗抑郁药(TCA)的心电图及对心电图的影响。心电图是通过在身体上放置电极来记录心脏的电导率。抗抑郁药对抑郁症患者的神经系统和心血管系统有致命的影响。TCA可引起心电图异常。它通过阻断钠通道来影响传导率和减慢心跳，从而导致QST复合物的延伸，从而导致异常。男性> 440ms，女性> 460ms QT延长。由于TCA, QT > 500ms导致异常。Brugada综合征也可因接触TCA而产生。多虑平减缓重度抑郁症患者的传导速率。TCA可导致已有心血管疾病患者出现症状性A-V阻塞。地西帕明和丙咪嗪可导致6-9岁儿童因过量服用这些药物而猝死。抗抑郁药如阿戈美拉汀、帕罗西汀、血清素再摄取抑制剂会导致患者和孕妇心脏畸形。心电图的异常告诉我们心脏节律性的问题。心电图可用于评估具有电生理作用的药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Scientific Inquiry and Review

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