Post COVID-19 effect of ovarian reserve

Abstract

Introduction: The SARS-CoV-2 infection's rise in circulating Ang II can change ovarian function, affect how oocytes develop and mature biologically, affect the quality of oocytes produced, and eventually reduce reproductive function Aim of the study: to evaluate how COVID-19 infection affects women undertaking assisted reproductive technology (ART) treatment for primary or secondary infertility. Subjects and Methods: A cross-sectional analytical study conducted at the Gynecology and Obstetrics department at Fayoum University Hospital saw 120 infertile (primary or secondary infertility) women who had verified prior COVID-19 infection as part of this cross-sectional analytical study. For all the study's female participants Results: In the current study, we included 120 infertile women with confirmed COVID-19 infection who had an average age of (26.96 ± 5.68) years, an average BMI of (21.8 ± 7.62) kg/m2, an average duration of (3.95 ± 1.16) months, a mild form of the disease reported by 86 (71.7%), a severe form reported by 30 (25%), and only a moderate form reported by four women (3.3%). According to the severity of the disease, the AMH, AFC, FSH, and LH mean serum levels measured after COVID-19 infection did not differ statistically significantly from the mean serum levels examined before COVID-19 infection ( P >0.05 ). before COVID-19 infection in the three groups according to disease severity ( P >0.05 ). Conclusions: The results of the study demonstrated that the COVID-19 virus had no impact on ovarian reserve; nevertheless, changes in menstruation status may be brought on by the severe inflammatory reaction and immune response of the COVID-19 disease or by psychological stress and anxiety.