Anti-Senescence Therapy

Raghad Alshadidi
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Abstract

The development of therapeutic strategies aimed at the aging process of cells has attracted increasing attention in recent decades due to the involvement of this process in the development of many chronic and age-related diseases. Interestingly, preclinical studies have shown the success of a number of anti-aging approaches in the treatment of a range of chronic diseases. These approaches are directed against aging processes such as oxidative stress, telomerase shortening, inflammation, and deficient autophagy. Many strategies has been shown to be effective in delaying aging, including antiaging strategies based on establishing healthy lifestyle habits and pharmacological interventions aimed at disrupting senescent cells and senescent-associated secretory phenotype. Caloric restriction and intermittent fasting were reported to activate autophagy and reduce inflammation. In turn, immune-based strategies, senolytic agents, and senomorphics mediate their effects either by eliminating senescent cells through inducing apoptosis or by disrupting pathways by which senescent cells mediate their detrimental effects. In addition, given the association of the decline in the regenerative potential of stem cells with aging, many experimental and clinical studies indicate the effectiveness of stem cell transplantation in preventing or slowing the progress of age-related diseases by enhancing the repairing mechanisms and the secretion of many growth factors and cytokines.
Anti-Senescence疗法
近几十年来,针对细胞衰老过程的治疗策略的发展引起了越来越多的关注,因为这一过程涉及许多慢性和年龄相关疾病的发展。有趣的是,临床前研究表明,许多抗衰老方法在治疗一系列慢性疾病方面取得了成功。这些方法是针对老化过程,如氧化应激,端粒酶缩短,炎症,和缺乏自噬。许多策略已被证明在延缓衰老方面是有效的,包括基于建立健康生活习惯的抗衰老策略和旨在破坏衰老细胞和衰老相关分泌表型的药物干预。据报道,热量限制和间歇性禁食可以激活自噬并减少炎症。反过来,基于免疫的策略、抗衰老药物和衰老形态通过诱导凋亡消除衰老细胞或通过破坏衰老细胞介导其有害作用的途径来调节其作用。此外,鉴于干细胞再生潜能的下降与衰老有关,许多实验和临床研究表明,干细胞移植可以通过增强修复机制和许多生长因子和细胞因子的分泌来预防或减缓衰老相关疾病的进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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