Oral Administration of Aqueous Leaf Extract of Ocimum Gratissimum Ameliorates Polyphagia, Polydipsia and Weight Loss in Streptozotocin-Induced Diabetic Rats

Abstract

The effects of oral administration of aqueous leaf extract of Ocimum gratissimum (OG) on food, water intake and weight changes in streptozotocin (STZ)-induced diabetic Albino Wistar rats was studied. Eighteen rats were randomly assigned into 3 groups of 6 rats each for control, diabetic (DM) and diabetic-treated (DMT) groups. Diabetes mellitus was induced in the test groups (DM and DMT) by a single dose of STZ (65 mg/kg, i.p.). The extract was administered per oral to the DMT group at a dose of 1500 mg/k body weight daily for 28 days. All the groups were fed normal rat chow and al- lowed water freely. The fasting blood glucose levels in the DM and DMT groups were higher (P<0.001) than the control group, with the DMT group lower (P<0.01) than the DM group. There was a significant (P<0.05) loss of body weight in the DM group compared to the control (P<0.01) and DMT (P<0.05) groups. There was an increase (P<0.01) in volume of wa- ter taken by the test groups compared to the control. The water intake in DMT group was lower (P<0.01) than the DM group. The food intake in the DM group was greater (P<0.001) than the control and DMT groups, with the later higher (P<0.05) than the control group. We therefore conclude that Ocimum gratissimum reduces blood sugar level in STZ-induced diabetic rats and alleviates the cardinal symptoms of diabetes mellitus namely; polydypsia, polyphagia and weight loss.