Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell

Abstract

Drug resistance is a frequent clinical problem that seriously reduces the efficacy of many chemotherapy agents. In this study, the effect of micellar encapsulation using poly(L-lactide)-vitamin E TPGS (PLA-TPGS) copolymer on intracellular distribution of doxorubicin was studied in vitro. As our results, doxorubicin can be encapsulated successfully into PLA-TPGS formed micelle with a uniform particle size (≪ 200nm) that could exhibit the passive targeting ability to cancer tissue. Moreover, the nuclear accumulation of doxorubicin can be improved significantly in micelle form that can utilize as a potential carrier to overcome doxorubicin-resistance in breast MCF-7 cancer cells.