A STUDY ON AETIOPATHOGENESIS AND MANAGEMENT OF NASAL POLYPOSIS

Abstract

Source of Funding: Self Conflicts of interest: None DOI: 10.16965/ijims.2019.119 Nasal polyps are one of the most common inflammatory mass lesions of the nose. Their etiology remains unclear, but they are known to have associations with allergy, asthma, infection, fungus,cystic fibrosis, and aspirin sensitivity. However, the underlying mechanisms interlinking these pathologic conditions to nasal polyp formation remain unclear. In the present cross-sectional study was carried with 100 patients diagnosed with nasal polyposis in the age group of 10-60 years of both the sexes were studied during this period from June 2014 to October 2015 in the department of ENT, Kakatiya medical college attached to MGM Hospital, Warangal were found in large majority age groups of 11 – 30 years, men are most commonly seen affecting than women (men: women are 2:1).Allergic rhinitis is strongly associated with nasal polyposis, most common symptom is nasal obstruction, anosmia and facial pain are also seen.Most of the patients had nasal polyps reaching beyond the middle turbinate. And also, most of the patients had bilateral ethmoidalopacification on CT scan.only few showed sphenoid and frontal opacities.Steroid therapy was useful in 38% of patients.All others required endoscopic sinus surgery. Also, strong genetic factors are implicated in the pathogenesis of nasal polyps, but genetic and molecular alterations required for its development and progression are still unclear.