Comparing the efficacy of lycopene & lycopene with hyaluronidase in management of oral sub mucous fibrosis-A clinical study

Md. Asdullah, Juhi Gupta, Shahla Khan, Prommod Yadav, N. A. Salati, Prathuman Verma
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Abstract

Oral submucous fibrosis (OSMF) is a scarring disease of the oral cavity that develops over time. Lycopene is a potent antioxidant found in tomatoes that has the best singlet oxygen quenching capability and a strong capacity to quench other free radicals in vitro of all the dietary carotenoids. A protein called hyaluronidase, which is found in mammalian sperm and testes, hydrolyzes hyaluronic acid to alter the permeability of connective tissue.To determine the effectiveness of lycopene and lycopenehyaluronidase in treating OSMF, as well as a comparison of their effectiveness.: 45 people with OSMF were enrolled in the study and divided into three groups. Patients in Group A received two evenly divided doses of Lycored 16 mg twice daily for three months. Patients in Group B received LycoRed and a 1500 IU intralesional injection of hyaluronidase twice a week for three months. Patients in Group C received placebo pills. The patients were evaluated at the end of three months. We observed the opening of the mouth, visual examination, palpatory findings, and burning sensation.For lycopene and lycopene–hyaluronidase combination, there was a statistically significant difference in mouth opening and burning sensation compared to placebo.
番茄红素及番茄红素联合透明质酸酶治疗口腔黏膜下纤维化的临床研究
口腔黏膜下纤维化(OSMF)是一种随时间发展的口腔瘢痕性疾病。番茄红素是一种有效的抗氧化剂,在所有的膳食类胡萝卜素中,番茄红素具有最好的单线态氧猝灭能力和很强的体外灭自由基能力。一种叫做透明质酸酶的蛋白质存在于哺乳动物的精子和睾丸中,它可以水解透明质酸来改变结缔组织的通透性。确定番茄红素和番茄红素透明质酸酶治疗OSMF的有效性,并比较其有效性。45名OSMF患者参加了这项研究,并被分为三组。A组患者接受2次均匀剂量的Lycored 16 mg,每天2次,持续3个月。B组患者接受LycoRed和1500iu局部注射透明质酸酶,每周2次,持续3个月。C组患者服用安慰剂。三个月后对患者进行评估。我们观察了开口,目视检查,触诊结果和烧灼感。对于番茄红素和番茄红素-透明质酸酶组合,与安慰剂相比,在开口和烧灼感方面有统计学上的显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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