The Role of Human Papilloma Virus in the Development of Oral Squamous Cell Carcinoma in Pakistani Population

Abstract

Pakistan is one of the high-risk countries for oral cancer development, where oral cancer is the most prevalent cancer in men and may account for up to 30% of all new cases of cancer per year, compared to 3% in the UK and 6% in France [1]. Many known etiological factors for oral cancer development, like Pan, Betel Nut, Areca nuts and smoking are very commonly used in Pakistan, however not all the people exposed to these factors develop cancer. Furthermore, many patients not exposed to any of these factors develop cancer. This indicates the presence of additional risk factors, including Human Papilloma Virus that can make these people more susceptible to cancer.