[Psychosine-induced changes in neuromuscular transmission and in the structure of the neuromuscular junction in the frog].

Abstract

A decrease in the amplitude of miniature and evoked end-plate potentials (MEPPs and EPPs) as well as changes in EPP facilitation and depression during frequency stimulation were observed in psychosine-treated m. cutaneous-pectoris of the frog. Electron-microscopic investigation demonstrated severe changes in synaptic Schwann cells embracing motor terminals and disturbances in the inner mesaxon structure of the myelinated parts of motor terminals.