Effect of geometrical shapes on 3D hydrodynamic focusing of a microfluidic flow cytometer

2016 IEEE International Conference on Semiconductor Electronics (ICSE) Pub Date : 2016-08-01 DOI:10.1109/SMELEC.2016.7573604

Muhammad Syafiq Rahim, N. Selamat, J. Yunas, A. Ehsan

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引用次数: 2

Abstract

This paper focuses on the effect of geometrical cross section between rectangular and circular shapes on the hydrodynamic focusing of a micro flow cytometer device. The effect of fluid flow ratio between the main and sheath channels on the focusing width is studied. This study has been performed using a COMSOL Multiphysics simulation tool. The results showed that focusing width decreases as the ratio between main channel and sheath channels are increased. The concentration at long-range is studied and indicated that circular shape can sustain a higher concentration at the centre along the channel compared with rectangular shape. The velocity at the cross-section of the channel-junction shows that circular shape produces higher velocity at the centre of the channel compare to that of the rectangular shape. The effect of flow ratio and geometrical shape are significantly vital for microfluidic system which utilizes hydrodynamic focusing for biological and chemical analysis. From the result, micro flow cytometer studied able to use for human body cells such as glucose, virus, red blood cells and white blood cells which have a range size of 2-120 microns.

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几何形状对微流控流式细胞仪三维流体动力聚焦的影响

本文研究了矩形和圆形几何截面对微流式细胞仪流体动力聚焦的影响。研究了主通道与护套通道间流体流量比对聚焦宽度的影响。这项研究是使用COMSOL多物理场模拟工具进行的。结果表明:随着主通道与鞘通道比值的增大，聚焦宽度减小;对长程浓度进行了研究，结果表明，与矩形形状相比，圆形形状可以在通道中心维持更高的浓度。在通道交界处横截面处的速度表明，圆形通道比矩形通道在通道中心产生更高的速度。对于利用流体动力聚焦进行生物化学分析的微流控系统来说，流量比和几何形状的影响至关重要。结果表明，微流式细胞仪能够用于检测人体细胞，如葡萄糖、病毒、红细胞和白细胞，其大小范围为2-120微米。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

2016 IEEE International Conference on Semiconductor Electronics (ICSE)

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