Assessment of biochemical parameters and hematological profile in the chronic renal failure of pre and post dialysis at Martyr Mohammed El-Najjar Hospital in Rafah, Gaza Strip, Palestine

Abstract

Background: There are limited data on the assessment biochemical and hematological profile in the chronic renal failure of pre and post dialysis in the Gaza Strip. Objective: To evaluating some biochemical parameters and hematological profile in the chronic renal failure of pre and post dialysis at Martyr Mohammed El-Najjar Hospital in Rafah, Gaza Strip, Palestine. Methods: Forty-three (end-stage renal disease) ESRD patients, aged 20-70 years old who were referred to Martyr Mohammed Youssef Al-Najjar Hospital in Rafah for the dialysis department. 43 apparently healthy individuals matched for ages were used as a control group for comparisons. Results: The results showed that post-dialysis higher statistically significant in Hb, RBC, HCT, PLT, AST, ALT, ALP and Ca level than pre-dialysis. While Ph, WBC, RDW, creatinine, Urea was lower statistically significant in post-dialysis than pre-dialysis (P < 0.05). Conclusion: chronic kidney disease shows abnormal hematological parameters, precisely reduced levels of RBC count, hemoglobin, hematocrit, and platelet count, in addition, pre-dialysis patients are more anemic and thrombocytopenic than post-dialysis patients and this is may indicate of lack of blood pressure and diabetic control in these patients. AST& ALT activities vary in concentration before and after dialysis and make the post-dialysis patients are higher than pre-dialysis.