The vasopressin positive elements in the hypothalamic magnocellular nuclei of rats treated with histamine.

Biological structures and morphogenesis Pub Date : 1992-01-01

A López-Muñiz, I Cuesta-Fernández, J De Miguel

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Abstract

The vasopressin (AVP) positive elements of the hypothalamic supraoptic (SON) and paraventricular (PVN) nuclei, were investigated in 180 male rats through immunohistochemical, morphometric and statistical methods. The rats were subdivided in the next groups: 20 control rats; 40 rats treated with physiological saline intraperitoneal via (ip); 40 rats treated with physiological saline intracerebroventricular via (icv); 40 histamine (HA) treated rats, ip; and 40 HA treated rats, icv. The labeled nerve cells appear in the lateral part of the PNV and the SON of the control animals. These neurons have central nucleus and vasopressin positive cytoplasmic granulations. After the treatment with physiological saline, ip or icv, no alterations were observed. In HA treated rats, icv, numerous neurons strongly labeled were observed in these hypothalamic nuclei. Vasopressin positive nerve fibers and large droplets were also found both in the SON and in the PVN of these animals. The vasopressin positive material in the control rats and in HA treated rats, ip, is similar. The morphometric and statistical studies confirm these findings. The results are discussed in this paper.

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组胺处理大鼠下丘脑大细胞核抗利尿激素阳性成分。

采用免疫组化、形态计量学和统计学方法，对180只雄性大鼠下丘脑视上核(SON)和室旁核(PVN)的抗利尿激素(AVP)阳性成分进行了研究。将大鼠再细分为下一组:对照组大鼠20只;40只大鼠经(ip)腹腔灌胃生理盐水;40只大鼠经脑室灌胃生理盐水;40组胺(HA)处理大鼠，ip;40只HA处理大鼠，icv。标记的神经细胞出现在对照动物的PNV外侧和SON中。这些神经元有中央核和抗利尿激素阳性的细胞质颗粒。经生理盐水、ip或icv治疗后，未观察到任何改变。在透明质酸处理的大鼠中，icv在这些下丘脑核中观察到大量强烈标记的神经元。在这些动物的SON和PVN中也发现了抗利尿激素阳性的神经纤维和大滴。抗利尿激素阳性物质在对照大鼠和HA处理大鼠中是相似的。形态计量学和统计学研究证实了这些发现。本文对所得结果进行了讨论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biological structures and morphogenesis

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