[Changes in spirometric values induced by nasally administered beclomethasone dipropionate in patients with perennial allergic rhinitis].

R Bilancia, F Federici, D G Ricatti, L Buonpensiere, A Ferrannini, E Gramiccioni
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Abstract

Authors showed that it's possible to control the asthmatic component in patients with persistent allergical rhinitis without bronchodilatory drugs. AA. compared two groups of ten patients: Group A has been treated with antihystaminical drugs or ketotifen per os and Disodium chromoglycate per nasal spray, Group B has been treated with the same drugs and Beclomethasone Dipropionate per nasal spray more (400 mcg a day). Respiratory functionality tests (FEV1 and MEF75) have been carried out at the beginning and at the end of the trial and the subsequent clinical parameters have been considered: dispnoea attacks, rhinorrhaea, sneezes, lost working or school days. The results of the study showed after three months of therapy a statistically significant improvement of FEV1 and MEF75 in Group B only; moreover the patients of the Group B had lower number of asthmatic attacks then patients of the Group A.

[常年性变应性鼻炎患者经鼻给药二丙酸倍氯米松诱导肺活量测定值的变化]。
作者认为,在不使用支气管扩张性药物的情况下,可以控制持续性变应性鼻炎患者的哮喘成分。AA。比较了两组10例患者:A组使用抗痫药物或酮替芬和糖化二钠鼻喷雾剂治疗,B组使用相同药物和双丙酸倍氯米松鼻喷雾剂治疗(每天400微克)。在试验开始和结束时进行了呼吸功能测试(FEV1和MEF75),并考虑了随后的临床参数:感冒发作、鼻出血、打喷嚏、失去工作或上学时间。研究结果显示,治疗3个月后,仅B组FEV1和MEF75有统计学意义的改善;B组哮喘发作次数明显低于A组。
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