[The mechanisms of the manifestation of the genotoxic effects of binase].

O B Ivanchenko, O N Il'inskaia, N S Karamova, I E Cherepneva
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Abstract

The high concentrations of commercial sample of Bacillus intermedius 7P ribonuclease (binase) showed a weak mutagenic effect in Ames test and Ara-test. It has been established that binase induces the SOS-functions of microbial cell and prophage induction. The way of exogenic enzyme action through activation of RecA protein is proposed.

[二酶基因毒性作用的表现机制]。
高浓度中芽孢杆菌7P核糖核酸酶(二酶)在Ames试验和ara试验中表现出弱诱变作用。已证实二酶可诱导微生物细胞的sos功能和原噬菌体的诱导。提出了外源酶通过激活RecA蛋白发挥作用的途径。
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