A clinical comparative study of 99Tcm-tetrofosmin with 99Tcm-MIBI in breast carcinoma and axillary lymph node metastases

Abstract

Objective To evaluate the clinical diagnostic value of 99Tcm-tetrofosmin in the imaging of breast carcinoma and axillary lymph node metastases and to compare with that of 99Tcm-MIBI Methods 52 females with breast masses were examined by 99Tcm-tetrofosmin scintigraphy and 99Tcm-MIBI scintigraphyAll the results were compared with that from pathologic study Results 26 patients were found to have a primary malignancy of the breast ,whereas 30 had benign disease 99Tcm-tetrofosmin breast imaging showed abnormal uptake in 21 of 26 malignancies and in 11 of 16 axillary lymph node metastasesThe sensitivity ,specificity, and accuracy values obtained with 99Tcm-tetrofosmin and 99Tcm-MIBI scintigraphy for breast carcinoma were 808%, 767%, 786%,and 731%,733%,732%, respectively The values obtained with 99Tcm-tetrofosmin and 99Tcm-MIBI scintigraphy for axillary lymph node metastases were 688%, 800%, 760%,and 750%,800%,769%, respectively Conclusions Both of the two techniques are effective in the differentiation of malignant breast mass-es from benign ones and in detecting axillary lymph node metastasesHowever , 99Tcm-tetrofosmin is superior to 99Tcm-MIBI in detecting breast carcinoma