Oxidative Stress and Vanadium

Genotoxicity and Mutagenicity - Mechanisms and Test Methods Pub Date : 2020-01-10 DOI:10.5772/intechopen.90861

M. Rojas-Lemus, P. Bizarro-Nevares, N. López-Valdez, A. González-Villalva, Gabriela Guerrero-Palomo, Cervantes-Valencia María Eugenia, Otto Tavera-Cabrera, Norma Rivera-Fernández, Brenda Casarrubias-Tabarez, M. Ustarroz-Cano, Armando Rodríguez-Zepeda, F. Pasos-Nájera, T. F. Goes

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引用次数: 5

Abstract

Air pollution is a worldwide health problem, and metals are one of the various air pollutants to which living creatures are exposed. The pollution by metals such as: lead, cadmium, manganese, and vanadium have a common mechanism of action: the production of oxidative stress in the cell. Oxidative stress favors the production of free radicals, which damage biomolecules such as: DNA, proteins, lipids, and carbohydrates; these free radicals produce changes that are observed in different organs and systems. Vanadium is a transition element delivered into the atmosphere by the combustion of fossil fuels as oxides and adhered to the PM enters into the respiratory system, then crosses the alveolar wall and enters into the systemic circulation. In this chapter, we will review the oxidative stress induced by vanadium—as a common mechanism of metal pollutants—; in addition, we will review the protective effect of the antioxidants (carnosine and ascorbate).

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氧化应激和钒

空气污染是一个世界性的健康问题，金属是生物接触到的各种空气污染物之一。铅、镉、锰、钒等金属的污染有一个共同的作用机制:在细胞中产生氧化应激。氧化应激有利于自由基的产生，自由基会破坏生物分子，如:DNA、蛋白质、脂质和碳水化合物;这些自由基产生的变化可以在不同的器官和系统中观察到。钒是一种过渡元素，通过化石燃料的燃烧以氧化物的形式释放到大气中，并附着在PM上进入呼吸系统，然后穿过肺泡壁进入体循环。在本章中，我们将回顾钒-作为一种常见的金属污染物引起的氧化应激机制;此外，我们将回顾抗氧化剂(肌肽和抗坏血酸)的保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genotoxicity and Mutagenicity - Mechanisms and Test Methods

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