[Hereditary motor and sensory neuropathy].

Abstract

The report consisted of 10 cases of hereditary motor and sensory neuropathy (HMSN). There were 7 males and 3 females. Their ages ranged from 11 to 42 (average 24.6) years, ages of onset varied from 7 to 34 (average 17.3) years. Hereditary history was showed in 4 cases. The clinical features of all 10 cases had peroneal muscular atrophy, 8 of 10 cases also had involvement of the upper limbs, 7 of 10 cases had pes arcuatus. The conduction velocity was obviously slow in 5 cases and slightly slow in the others. Oion-bulb hypertrophic neuropathy was demonstrated in sural nerve biopsies of 5 cases. Neuronal axonal degeneration were found in the remaining 5 cases. Clinical classification, clinical features and pathological characteristics were discussed.