Lipid and apoprotein markers and carotid intima-media thickness among hypertensive Nigerians

M. Kuti, A. Adeoye, S. Agboola, Tolulope Olutosin Omilakin
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Abstract

Context: Measurement of lipids and apoproteins are essential components aimed at reducing the global burden of atherosclerotic cardiovascular disease. Carotid intima-media thickness (CIMT) has been widely accepted as an index of subclinical atherosclerosis. A relationship between CIMT and the parameters of the traditional lipid profile has been described. Aim: Evaluation of the diagnostic character of lipid and apoprotein markers, which are cheap and easy to perform, in detecting a significant thickening of the carotid intima media in hypertensive persons. Subjects and Methods: Cross-sectional study of adult male hypertensive persons with fasting measurement of the traditional lipid profile and apoprotein B. CIMT of the common carotid artery was determined by ultrasound in all participants. Results: The mean CIMT was significantly higher among the hypertensive participants than normotensive controls. Age, systolic blood pressure, triglycerides, low-density lipoprotein-cholesterol (LDL-C), and Apo B were all significantly associated with CIMT. Hypertensive persons with CIMT ≥1.00 mm had significantly higher serum concentrations of total cholesterol (TC), LDL-C, and Apo B. The positive predictive value of a result (TC >200 mg/dL, LDL-C >130 mg/dL, and Apo B >100 mg/dL) was <50%, while that for a negative result (TC <200 mg/dL, LDL-C <130 mg/dL, and Apo B <100 mg/dL) approached or was equal to 100%. Conclusions: There is some relationship between dyslipidemia and significant thickness of the carotid intima media. The levels of TC, LDL-C, and Apo B in plasma, which are cheaper and easier to determine, may help in the selection of hypertensive persons to be offered CIMT assessment.
尼日利亚高血压患者的脂质和载脂蛋白标志物及颈动脉内膜-中膜厚度
背景:脂质和载脂蛋白的测量是减少动脉粥样硬化性心血管疾病全球负担的重要组成部分。颈动脉内膜-中膜厚度(CIMT)已被广泛接受为亚临床动脉粥样硬化的指标。描述了CIMT与传统脂质谱参数之间的关系。目的:探讨脂质和载脂蛋白标志物在高血压患者颈动脉内膜明显增厚中的诊断价值。脂质和载脂蛋白标志物价格便宜,操作简便。对象和方法:对成年男性高血压患者进行横断面研究,空腹测量传统的血脂和载脂蛋白b。所有参与者均采用超声检测颈总动脉的CIMT。结果:高血压患者的平均CIMT明显高于正常对照组。年龄、收缩压、甘油三酯、低密度脂蛋白-胆固醇(LDL-C)和载脂蛋白B均与CIMT显著相关。CIMT≥1.00 mm的高血压患者血清总胆固醇(TC)、LDL-C和Apo B浓度明显升高,阳性预测值(TC > 200mg /dL、LDL-C > 130mg /dL、Apo B > 100mg /dL) <50%,阴性预测值(TC < 200mg /dL、LDL-C < 130mg /dL、Apo B < 100mg /dL)接近或等于100%。结论:血脂异常与颈动脉中内膜明显厚度有一定关系。血浆中TC、LDL-C和载脂蛋白B的水平更便宜、更容易测定,可能有助于选择接受CIMT评估的高血压患者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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