Effects of pineal-derived indolic compounds and of certain neuropeptides on the growth processes in the thyroid gland.

Thyroidology Pub Date : 1992-04-01

A Lewiński, E Wajs, M Karbownik

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Abstract

The aim of the present study was to examine the effects of melatonin (Mel) and of pinealectomy (PX) [in a long-term experiment in vivo - 10 weeks], as well as of Mel and N-acetylserotonin (NAc-5HT) [in experiments ex vivo in vitro and in vitro], on the rat thyroid growth processes. Additionally, the incubations in vitro of rat thyroid lobes with 3H-thymidine, in the presence of TSH, vasoactive intestinal polypeptide (VIP), VIP-antagonist ([4Cl-D-Ph6, Leu17]VIP), somatostatin (SS), all the substances used separately or jointly in combinations, were performed. It was shown that: (a) Mel--administered in late afternoon injections--decreased, while PX increased examined indices of thyroid growth in vivo, (b) Mel--administered in s.c. implanted pellets--reversed the inhibitory effect of Mel injections, (c) in experiments ex vivo in vitro and in vitro, the inhibitory effect of Mel revealed only for the lowest applied dose/concentration of the hormone, (d) NAc-5HT showed no effect, (e) VIP decreased 3H-thymidine incorporation into DNA of thyroid lobes in vitro and enhanced the inhibitory effect of SS on the process in question, (f) VIP-antagonist failed to reverse the inhibitory action of VIP on the thyroid growth.

本刊更多论文

松果体衍生的吲哚化合物和某些神经肽对甲状腺生长过程的影响。

本研究的目的是研究褪黑激素(Mel)和松果体切除术(PX)[在体内- 10周的长期实验中]，以及褪黑激素和n -乙酰5 -羟色胺(NAc-5HT)[在体外和离体实验中]对大鼠甲状腺生长过程的影响。此外，在TSH、血管活性肠多肽(VIP)、VIP拮抗剂([4Cl-D-Ph6, Leu17]VIP)、生长抑素(SS)存在下，分别或联合使用3h -胸腺嘧啶对大鼠甲状腺叶进行体外培养。结果表明:(a)下午晚些时候注射Mel-减少，而PX增加了体内甲状腺生长的检查指标，(b) Mel-在s.c.植入颗粒中注射-逆转了Mel注射的抑制作用，(c)在离体和体外实验中，Mel仅对最低剂量/浓度的激素有抑制作用，(d) NAc-5HT没有作用。(e) VIP降低了体外甲状腺叶DNA中3h -胸腺嘧啶的掺入，增强了SS对该过程的抑制作用;(f) VIP拮抗剂未能逆转VIP对甲状腺生长的抑制作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Thyroidology

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