Morphological Aspects of the Pathogenesis of Gallbladder Cholesterosis

Abstract

The article presents a new view on the pathogenesis of cholesterosis of the gallbladder, formed on the basis of the morphological study of a large number of gallbladders after cholecystectomy using modern. Methods: Light and electron microscopy, immunohistochemistry. Essentially new information is given on the structure of the gallbladder wall and its pathomorphosis in the dynamics of the disease. The phenomenon of endocytosis absorption of bile micelles by absorptive epithelial cells and their penetration into their own plate is described for the first time. It is this process that triggers the activation of histiocytes and their transformation into tissue macrophages. For the first time, using immunohistochemistry, it was proved that only macrophages are the phenotypic precursor of foam cells. Conclusion: The etiological factor of cholesterosis is general disorders of the body’s lipid metabolism and the following changes in the metabolizing properties of absorbent biliary epithelium cells, as well as the synthetic and secretory functions of tissue macrophages.