Nano-featured highly interconnective macroporous elastic scaffolds for cardiovascular tissue engineering

Abstract

The lack of suitable scaffolding materials and viable scaffold design is challenging the success of tissue engineering. In the present study, we developed a new scaffolding strategy using a secondary porogen, poly(ethylene glycol) dimethyl ether along with sieved salts based on traditional salt-leaching method. This new scaffolding technology could allow us to fabricate nano- featured highly interconnective macroporous biodegradable elastic scaffolds based on a newly developed crosslinked poly(l,8-octanediol citrate) (POC) for cardiovascular tissue engineering.