Therapeutic effect of Vitamin C on electroporation mediated muscle injury in vivo

Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136) Pub Date : 1997-10-30 DOI:10.1109/IEMBS.1997.756827

G. Abramov, M. Bier, J. Hannig, R.C. Lee

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Abstract

High voltage electrical shock can produce extensive muscle and nerve tissue damage due to thermal denaturation of proteins and poration of cell membranes by electric field gradients. To study the therapeutic effect of Vitamin C on the neurophysiologic performance of motor nerves following electrical injury, the authors used an in vivo model exposing an anesthetized rat's hindlimb to thermally neutral electrical shocks. The applied pulsed electrical fields had a strength of approximately 150 V/cm. A standard EMG test was used to monitor the damage and recovery of the motor nerve function. Intravenously administered Vitamin C at concentrations of 5.8 mg/kg and 340 mg/kg showed a dose-dependent, statistically significant improvement in the recovery of the muscle action potential amplitude.

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维生素C对电穿孔介导的肌肉损伤的治疗作用

由于电场梯度使蛋白质热变性和细胞膜穿孔，高压电击可造成广泛的肌肉和神经组织损伤。为了研究维生素C对电损伤后运动神经生理功能的治疗作用，作者采用麻醉大鼠后肢热中性电刺激的体内模型。施加的脉冲电场强度约为150 V/cm。采用标准肌电图监测运动神经功能损伤及恢复情况。静脉注射浓度为5.8 mg/kg和340 mg/kg的维生素C对肌肉动作电位振幅的恢复有剂量依赖性的统计学显著改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Proceedings of the 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 'Magnificent Milestones and Emerging Opportunities in Medical Engineering' (Cat. No.97CH36136)

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