100 anni dopo l’insulina: cosa ancora non sappiamo della sua secrezione nel diabete di tipo 2

Il Diabete Pub Date : 2022-05-12 DOI:10.30682/ildia2201c
Gianfranco Di Giuseppe, Teresa Mezza, F. Cinti, A. Giaccari
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Abstract

β-cell dysfunction is a well-known feature of type 2 diabetes mellitus. In particular, it has been shown that defects in 1st phase insulin secretion play a fundamental role in the natural history of the disease. In this review, we highlight the clinical relevance of 1st phase impairment, focusing on its connection with post meal hyperglycemia and diabetic complications; we further evaluate possible therapeutic strategies aimed at improving β-cell secretory machinery and providing a durable control of the disease. In conclusion, we discuss the clinical relevance of C-Peptide sampling in detecting secretory defects.
胰岛素100年后,我们还不知道他在2型糖尿病中的分泌物
β细胞功能障碍是2型糖尿病的一个众所周知的特征。特别是,已经证明第一阶段胰岛素分泌缺陷在疾病的自然史中起着重要作用。在这篇综述中,我们强调了第一期损伤的临床意义,重点是它与餐后高血糖和糖尿病并发症的关系;我们进一步评估旨在改善β细胞分泌机制和提供疾病持久控制的可能治疗策略。总之,我们讨论了c肽取样检测分泌缺陷的临床意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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