HYPERPROLACTINAEMIA AS A POTENTIAL CAUSE OF INFERTILITY

Abstract

Establishing of hormonal disturbances is one of the most important steps in infertility studies. The aim of the study was to evaluate the importance frequency and treatment efficiency of hyperprolactinaemia in infertile patients. Eighty-seven infertile patients have been examined in this study. Matched samples of periph­eral blood were taken for hormonal analyses in the early follicular, periovulatory and midluteal phases of the cycle. Between the 4th and 7th day of the cycle ultrasonographic and haemodynamic examinations have been carried out at the ovarian and uterine levels. Hyperprolactinaemia was detected in 25 women, in which prolactin levels ranged 628.4-8000 mIU/L. We started dopamine agonists (bromocriptine/cabergoline) treatment individually dosaged. Menstrual cycle as well as prolactin levels restored in all patients 3 months after treatment initiation. Hyperprolactinaemia can derange fertility potential so its early and precise detection and adequate therapy are essential for restoration of regular menstrual cycle and successful infertility treatment.