Lipidic nanoparticules: a model function to predict the transition temperature of DPPC-DMPC mixtures

F. E. Buffo, M. B. Sierra, V. Pedroni, M. A. Morini
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引用次数: 2

Abstract

Thermotropic behavior of unilamellar liposomes prepared from binary mixtures of phosphatidylcholines in aqueous suspensions was analyzed by means of the temperature dependence of the Zeta Potential (ZP). This technique presents high sensitivity and small amount of sample required, that is, 70% less than that required in the use of conventional calorimeters. A model function is proposed to adjust the thermotropic behavior of the DPPC-DMPC system. From the adjustment, temperature transition (Ttransition) data as a function of the composition are obtained. The objective of this paper is to propose, from those few Ttransition-composition data, a function that allows obtaining Ttransition for any composition of the mentioned system. Moreover, graph of phase boundaries for these mixed-lipid vesicles was constructed by plotting the delimiting temperatures of the main phase transition as a function of the lipid composition of the vesicle. The combination of the zeta potential technique and the mathematical processing of their data would be a simple and useful tool for determining the transition temperatures of more complex mixtures. Correspondence to: Laboratorio de Fisicoquímica, INQUISUR, Departamento de Química, Universidad Nacional del Sur (UNS)-CONICET, Av. Alem 1253, 8000 Bahía Blanca, Argentina , E-mail: mamorini@criba.edu.ar
脂质纳米粒子:预测DPPC-DMPC混合物转变温度的模型函数
利用ζ电位(ZP)的温度依赖性分析了磷脂酰胆碱二元混合物制备的单层脂质体的热致性。该技术灵敏度高,所需样品少,比传统量热计少70%。提出了一种调节DPPC-DMPC体系热致性的模型函数。通过调整,得到了温度转变(Ttransition)数据作为组分的函数。本文的目的是从这些少量的过渡-组成数据中提出一个函数,该函数允许对上述系统的任何组成获得t过渡。此外,通过绘制主要相变的定界温度作为囊泡脂质组成的函数,构建了这些混合脂质囊泡的相边界图。zeta电位技术和他们的数据的数学处理的结合将是一个简单而有用的工具,以确定更复杂的混合物的转变温度。联系地址:阿根廷国立南方大学Química系调查研究所Fisicoquímica实验室,阿莱姆大街1253,8000 Bahía,布兰卡,E-mail: mamorini@criba.edu.ar
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